A thermohydraulic linkage of machines, technical building equipment and the building itself is proven to improve energy efficiency by recovering waste heat and transforming it into useful energy. This approach increases the potential for savings, but inevitably leads to an increased complexity of the interacting sub-systems and automation solutions to control the energy production, storage and consumption. This paper presents a framework for an energy efficient and flexible operating strategy of supply systems within a thermally-linked factory. Additionally, an approach is presented to implement an interface for external control optimizers while ensuring the safe operation of supply grids and facilities.